LCP research projects

Current research in the Laboratory for Computational Physiology comprises two major projects:

Critical Care Informatics

Patients in hospital ICUs are physiologically fragile and unstable, generally have life-threatening conditions, and require close monitoring and rapid therapeutic interventions. They are connected to an array of equipment and monitors, and are carefully attended to by the clinical staff. A staggering amount of data is collected daily on each patient in an intensive care unit (ICU): multichannel waveform data sampled hundreds of times each second, trend data averaged each second or minute, alarms and alerts, lab results, imaging results, records of medication and fluid administration, staff notes and more. Petabytes of data are captured daily during care delivery in the country’s ICUs; however, most of these data are not used to generate evidence or to discover new knowledge. The technology now exists, however, to collect, archive, and organize highly granular ICU data, including physiologic waveforms, resulting in research resources of enormous potential. Work in our group has produced the publicly distributed and growing MIMIC-II database, which now holds detailed de-identified data spanning the entire ICU stay from about 40,000 admissions to the ICU's of Beth Israel Deaconess Medical Center (BIDMC) in Boston. The database is a priceless research resource and is critical for our future investigations. Its value is also recognized by many others; at present more than 1500 investigators world-wide have been granted access to MIMIC. They represent academia, clinical medicine, and industry from more than 32 countries.

Research Resource for Complex Physiologic Signals
The Laboratory for Computational Physiology is one of two core laboratories of the National Institutes of Health’s Research Resource for Complex Physiologic Signals, funded through NIBIB/NIGMS grant U01- EB008577. The LCP is also the home of the Resource’s PhysioNet web site, www.physionet.org, the world’s largest repository of freely available recorded physiologic signals, time series, and related open-source software for research.

Recent completed research projects:

Integrating Data, Models, and Reasoning in Critical Care

The objective of this NIH-sponsored Bioengineering Research Partnership (BRP), established in October 2003, is to develop and evaluate advanced ICU patient monitoring and decision support systems that will improve the efficiency, accuracy, and timeliness of clinical decision-making in critical care. This project is funded through 2013 by the National Institute of Biomedical Imaging and BioEngineering (NIBIB) under grant 2RO1-001659.